Other performers will include Stereophonics, The Magic Numbers and quirky film director Quentin Tarantino will also be a special guest.
The show, hosted by Welsh heartthrob Steve Jones and Jordie lass Lauren Laverne, will once again tour the country and feature the T-Mobile Street gigs segment, which sees bands play one-off intimate gigs.
Jones commented: “Friday nights are about to grow very big Transmission shaped balls. It’s series three and I promise they are going to be bigger and hairier than ever!”
The series kicks off with newcomer Nash, punk legend Siouxsie Sioux, - who is releasing new album Mantaray on September 10 – and rockers The Enemy. All three will perform in the rather luxurious surroundings of an Edwardian Turkish Bath in Manchester.
Other locations include London, Cardiff, Southampton and Glasgow.
Transmission with T-Mobile starts on Channel 4 on September 21 at 11.30pm. It will be repeated in a new slot on T4 every Saturday at 10.30am.